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Sol, Terra, and Luna, our GPT‑5.6 family of models, are starting to roll out now in ChatGPT, Codex, and the API. https://t.co/Qri7GdtYs3
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gpt-5-pro-2025-10-06 is a proprietary OpenAI llm model.
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Quality Score
1146
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Undisclosed
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Oct 2025
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Introducing GPT-5.2 | OpenAI Skip to main content Research Products Business Developers Company Foundation (opens in a new window) Log in Try ChatGPT (opens in a new window) Research Products Business Developers Company Foundation (opens in a new window) Try ChatGPT (opens in a new window) Login OpenAI December 11, 2025 Product Release Introducing GPT‑5.2 The most advanced frontier model for professional work and long-running agents. Loading… Share Model performance Model per
Introducing GPT-5.2 | OpenAI Skip to main content Research Products Business Developers Company Foundation (opens in a new window) Log in Try ChatGPT (opens in a new window) Research Products Business Developers Company Foundation (opens in a new window) Try ChatGPT (opens in a new window) Login OpenAI December 11, 2025 Product Release Introducing GPT‑5.2 The most advanced frontier model for professional work and long-running agents. Loading… Share Model performance Model per
View sourceWe audited SWE-Bench Pro, one of the most widely used AI coding benchmarks, and found it no longer reliably measures frontier coding capability. We find 30% of SWE-Bench Pro tasks to be broken, and are retracting our previous recommendation that the research community use it as
View sourceWe audited SWE-Bench Pro, one of the most widely used AI coding benchmarks, and found it no longer reliably measures frontier coding capability. We find the eval to be saturated at a ~70% noise ceiling, and are retracting our previous recommendation that the research community
View sourceWe audited SWE-Bench Pro, one of the most widely used AI coding benchmarks, and found it no longer reliably measures frontier coding capability. We find 30% of SWE-Bench Pro tasks to be broken, and are retracting our previous recommendation that the research community use it as
We audited SWE-Bench Pro, one of the most widely used AI coding benchmarks, and found it no longer reliably measures frontier coding capability. We find the eval to be saturated at a ~70% noise ceiling, and are retracting our previous recommendation that the research community
Current computational approaches for drug design typically focus on generating molecules conditioned on specific targets or general molecular properties, often neglecting the influence of disease context on target behavior and therapeutic outcomes. To address this gap, we introduce DrugGen-2, a novel generative model that designs small molecules conditioned on both disease ontology and target protein sequences. DrugGen-2 was developed by fine-tuning a pre-trained GPT-2 model on a curated dataset of approved drugs linked to their diseases and targets, using a two-step strategy of supervised fine-tuning followed by reinforcement learning via group relative policy optimization (GRPO). This process was guided by reward functions optimizing for chemical validity, novelty, diversity, and high predicted binding affinity. When evaluated on five protein targets relevant to diabetic nephropathy, DrugGen-2 significantly outperformed baseline models (DrugGPT and DrugGen). It demonstrated a superior capacity to generate unique molecules, exhibited greater structural similarity to approved drugs, and achieved improved predicted binding affinities across all targets. Molecular docking analyses further supported these findings, identifying candidate ligands with strong binding potential, including compounds with predicted affinities (-9.917, -9.485, and -9.367) exceeding those of reference drugs such as enalapril for angiotensin-converting enzyme (-8.283). By integrating disease-specific context into molecular generation, DrugGen-2 advances AI-assisted drug discovery, offering a powerful tool for de novo design and drug repurposing that accounts for the complex interplay between diseases and molecular targets.
Multi-step LLM pipelines fail through interactions among retrieval, reasoning, and formatting steps, so prompt-only optimization can miss bottlenecks in the chain. We present FAPO (Fully Autonomous Prompt Optimization), a framework that lets Claude Code optimize an LLM pipeline inside a standardized codebase. FAPO evaluates a pipeline, inspects intermediate steps, diagnoses failures, proposes scoped changes, and validates variants repeatedly to optimize against a score function. It first tries prompt edits and, only when prompt optimization appears insufficient, changes chain structure within the permitted scope when attribution identifies a structural bottleneck. Across six benchmarks and three task models, FAPO beats the baseline GEPA in 15 of 18 model-benchmark comparisons. In 11 model-benchmark comparisons, FAPO wins with non-overlapping mean pm trial-standard-deviation ranges, and the mean FAPO-GEPA gain is +14.1 pp. In the six HoVer and IFBench comparisons where prompt-first search escalated to structural changes, FAPO wins all six with a mean gain of +33.8 pp. FAPO also improves performance on security tasks: on CTIBench-RCM, a security CVE-to-CWE task, prompt-only FAPO lifts test accuracy by +4.0 pp on GPT-5, +7.1 pp on Foundation-Sec-8B-Instruct, and +2.0 pp on Foundation-Sec-8B-Reasoning. These results position FAPO as a state-of-the-art pipeline optimization technique for both general-purpose and security-focused tasks.
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